Friday, April 29, 2011

Why should Endosulfan be banned?

An excellent summary of the current position regarding Endosulfan and its global ban, by Dr K. P. Aravindan, Professor of Pathology, Calicut Medical College..


There has been a lot of concern in the last few decades regarding organic chemicals that do not degrade, but persist and accumulate in the environment. These Persistent Organic Pollutants (POPs) are mostly organochlorine pesticides, but also include others like polychlorinated Biphenyls and Dioxins. The worry is that the accumulation would adversely affect marine and other life. There is plenty of evidence regarding this.

It was initially thought that Endosulfan - an organochlorine pesticide - degrades in the environment. In fact, the website of Excel Cropcare Ltd - the biggest producer of Endosulfan in the world - proclaims that “it is safe to use on parasites and predators and does not leave persistent residues in the environment – soil, plants and water”. This is now scientifically known to be untrue. US Environmental Protection Agency (USEPA) says in its 2002 document “based on environmental fate, laboratory studies, terrestrial field dissipation studies, available models, monitoring studies, and published literature, it can be concluded that Endosulfan is a very persistent chemical which may stay in the environment for lengthy periods of time, particularly in acid media’’.

Endosulfan does fulfil several of the criteria under the UNEP Stockholm Convention for designation as a POP. The alpha- and beta-isomer have similar physical-chemical properties and environmental behaviour to some of the obsolete organochlorine pesticides, although an assessment of their persistence and toxicity should be viewed alongside Endosulfan Sulfate, as ‘Sigmaendosulfan’. Persistence of ‘Sigmaendosulfan’, coupled with the continued use of endosulfan pesticides, will ensure continued long-range transport and contamination of remote environments like the Arctic. (Weber et al., “Endosulfan, A Global Pesticide: A Review of its Fate in the Environment and Occurrence in the Arctic”, Sci Total Environ. 2010 Jul 1;408(15):2966-84.)

There are many studies of organochlorine insecticides, including Endosulfan, acting as Endocrine disruptors. This means that these chemicals affect hormone levels including the reproductive hormones. Infertility, abortion, aberrant secondary sexual characteristics during adolescence and so on could result as surmised from extrapolations of animal studies. Obesity and Type 2 diabetes are some of the other problems shown in experimental animals exposed to prolonged low doses of these chemicals. The link between POPs and these diseases in human populations are coming to light now (Lee et al., “Low Dose Organochlorine Pesticides and Polychlorinated Biphenyls Predict Obesity, Dyslipidemia, and Insulin Resistance among People Free of Diabetes”, PLoS One. 2011;6(1):e15977). Studies have shown correlation between exposure to hormone disruptors during foetal development resulting in incomplete and deformed reproductive systems, reduced fertility and compromised immune systems in wildlife and impaired mental development, learning difficulties, hyperactivity and clear cell vaginal cancer in humans.

Endosulfan was sprayed through the aerial route on a heavily populated region in Kasargode, in effect contaminating their drinking water and food. This went on for two decades. Here was virtually an experiment, only difference was that it was being done on a human population. So, would the predictions hold true? What is the scientific evidence of the ill effects of hormone disruption?

(Representational only)
There have been three epidemiological studies done in the area. A small pilot study done by KSSP in 2001 in 153 households in the epicentre of Enmakaje panchayat compared to 441 households in the relatively less affected areas. This was followed by a well designed study conducted by the National Institute of Occupational Health (NIOH) an ICMR research institute in 2002-3 (Saiyed et al., “Effect of Endosulfan on Male Reproductive Development”, Environ Health Perspect., 2003 Dec;111(16):1958-62). Recently there has been another study done by the Community Medicine Department of the Calicut Medical College. All the three studies have reached near identical conclusions pointing to the effects of severe hormone disruption in this population.

There has been no scientific refutation of these studies. There was a ham handed attempt by a committee headed by O.P. Dubey to discredit the NIOH report. However, as I have pointed out earlier, this committee does not know even elementary statistics. Now, the Gujarat government has come forward with another committee report trying to trash the NIOH (incidentally located in Gujarat) study. This is mere rehash of the Dubey report and is prompted by the need to protect the pesticide companies and is a plain hatchet job. The scientifically inclined reader can judge this trash which is available at

Forgetting Dubey and Gujarat government and coming back to serious science, is the Kasargode experience a one-off affair due to very faulty application of science? Definitely, such things can happen again with some other pesticide being sprayed on people's heads incessantly. But remember that in case of persistent pollutants, their levels may build up in the environment and once it has been shown to be an endocrine disruptor in humans, there is no other way out than withdrawing it from the market. This is not all. Now reports are appearing that even without aerial spraying, human exposure to endocrine-disrupting chemicals can cause pre-natal risk factors for undescended testes and hypospadias. A nested case control study from Spain shows exactly this. (Fernandez et al., “Human exposure to endocrine-disrupting chemicals and prenatal risk factors for cryptorchidism and hypospadias: a nested case-control study”, Environ Health Perspect. 2007;115 Suppl 1:8-14).

I have written this long note to clarify on whose side good science is. On the one hand, you have an array of peer-reviewed literature and a cogent argument combining basic science, epidemiology, biological plausibility, and warning of risk and need for caution. What do you have on the other? Dubious Dubeys and Modi-appointed spokespersons for the pesticide lobby? What scientific literature is there in their hands that would persuade us to throw caution to the winds?

So this is not a fight between motivated politicians and screaming environmentalists versus scientists and rational arguers. This is between good science versus lies and propaganda dished out by an industry out to make the last few bucks from a doomed chemical.


  1. Endosulfan as I have read is a pesticide and you are saying that there are no negative effects to the environments. Therefore they are safe to use. It is safe to use on parasites and predators and does not leave persistent residues in the environment – soil, plants and water.

  2. @Tim Cooper:

    Your comment is totally incomprehensible. What are you trying to say?

  3. Most of the comments seem to be on the politicians and counter arguments against the ban. Before raising the flag for any side think about your food and our health. Any thing that happens in the farming will reach our body. Farming practices should not be seen isolated from our food issues. So it is better to see the issue “whether theses chemicals are needed for our and our children's body or not?” Don't get boggled down with the argument of food scarcity and hunger. None of us are going to change our life style or reduce our consumption to eradicate the poverty or hunger either at globsl level or at local level. They are the worries of the system managers - the govt. and certainly not of yours. Let us try to focus on our self. Do we need these kinds of chemicals in our food stuffs?

  4. There are some fundamental flaws in this report. Endosulfan is not an organo chlorine compound, but is an ester. It is biodegradable and does not bioaccumulate. It is quite impossible to have a level of 119 ppm of endosulfan in the system, as claimed by Dr. Mohan Kumar, since just 0.86 ppm of the chemical in the system can prove fatal. There have been umpteen number of studies on effect of endosulfan on endocrine disruption, mutagenicity, genotoxicity and embryotoxicity, all of which have failed to provide any conclusive evidence for these effects. After all, it is not an unknown fact that CES is an agent of antipesticide mafia of the Europe. Please go through this report :

  5. The formula of Endosulfan is 6,7,8,9,10,10-Hexachloro-1,5,5a,6,9,9a-hexahydro-,9-methano-2,4,3-benzodioxathiepine-3-oxide. Why does Dr Harish think it is not an organochlorine compound? Nothing prevents it from getting esterified. He is confusing the two. The rest of what he writes has nothing to do with what I have written. I don't think he has had the patience to read it through. The least he can do is not commit blunders so out in the open.